Renal blood flow autoregulation was preserved in both OP ( n = 7) and OR ( n = 7) rats. 2.0 ± 0.1 μm 3 × 10 −6) were similar between OP ( n = 6) and OR ( n = 9) rats. Potential hemodynamic mechanisms of renal injury were assessed in additional groups of OP and OR rats fed a moderately high-fat diet for 3 mo. 128 ± 2 mmHg, P < 0.05) and substantial levels of proteinuria (63 ± 12 vs. OP ( n = 10) rats developed modest hypertension (142 ± 3 vs. Radiotelemetrically measured blood pressure, proteinuria, and GS were assessed. ![]() Eight-week-old male obesity-prone (OP) and obesity-resistant (OR) rats (Charles River) were administered a moderately high-fat diet for 5 mo. We investigated if GS develops over longer periods of DIO and examined the potential role of hemodynamic mechanisms in its pathogenesis. The diet-induced obesity (DIO) model is frequently used to examine the pathogenesis of obesity-related pathologies however, only minimal glomerulosclerosis (GS) has been reported after 3 mo.
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